This study investigated the effects of sapogenins extracted from Spirulina platensis on telomerase activity in two different cell lines: MCF7 (a human breast cancer cell line) and HDF (human dermal fibroblasts). The findings revealed a dual effect, with sapogenins increasing telomerase activity in HDF cells, which are normal cells, while decreasing it in MCF7 cancer cells, suggesting potential therapeutic applications in promoting healthy cell aging and inhibiting cancer cell proliferation.