A study investigated the effects of zinc picolinate supplementation on oxidative stress and pulmonary function in patients with stable chronic obstructive pulmonary disease (COPD). After eight weeks of daily supplementation with 22 mg of zinc picolinate, patients exhibited significant increases in plasma superoxide dismutase (SOD) activity and zinc levels, suggesting improved antioxidant capacity; however, there were no significant changes in malondialdehyde (MDA) levels or pulmonary function test results, indicating that while zinc supplementation may enhance antioxidant defenses, it does not appear to affect lung function over this duration.