The study investigated the impact of Klamin®, an extract from the blue-green algae Aphanizomenon flos-aquae (AFA), on human colon muscle contractions. The findings revealed that Klamin® significantly reduced spontaneous contractions of the colon by activating trace-amine-associated receptor 1 (TAAR1) through its β-phenylethylamine (β-PEA) content, leading to serotonin release from enteric neurons, suggesting its potential as a natural remedy for intestinal motility disorders.