This study investigated how trehalose, a natural disaccharide, protects cells from oxidative stress by modulating the Keap1–Nrf2 and autophagy pathways. The findings revealed that trehalose not only induces autophagy but also increases the expression of p62, which in turn activates the Nrf2 pathway, leading to enhanced expression of antioxidant enzymes and reduced reactive oxygen species […]
This study investigated the protective effects of trehalose on bone marrow stromal cells (BMSCs) exposed to oxidative stress induced by hydrogen peroxide (H₂O₂). The findings revealed that pre-treatment with 3% trehalose enhanced cell survival by activating autophagy—evidenced by increased LC3II/LC3I ratios and decreased p62 protein levels—and reduced apoptosis, as indicated by lower expression of cleaved […]
The article discusses the intracellular protective functions of trehalose, highlighting its role in stabilizing proteins and cellular structures under stress conditions while also acting as an autophagy inducer. It explores the therapeutic potential of trehalose in various diseases, including neurodegenerative disorders, cardiovascular conditions, and metabolic diseases, due to its ability to modulate cellular recycling processes […]
This research investigates Trehalose as a naturally occurring disaccharide that plays a crucial role in cellular protection by stabilizing proteins and membranes, scavenging free radicals, and acting as an osmoprotectant under various stress conditions. Its therapeutic potential has been explored in the treatment of neurodegenerative diseases, diabetes, and cardiovascular disorders, primarily due to its ability […]
This study investigated the effects of trehalose on human cytomegalovirus (HCMV) infection. The findings revealed that trehalose induces autophagy through an mTOR-independent pathway, leading to a significant reduction in HCMV gene expression and viral replication across various human cell types, including fibroblasts, endothelial cells, and neural cells.
